Complete all story missions, including all assassination missions from Lester.
Get a lap dance at a strip club.
Complete all 5 Street Races. Street Races unlock after completing Hao's Shift Work mission with Franklin.
Complete all 4 Sea Races. Sea Races unlock after completing Hood Safari with Trevor.
Score at least a Bronze in 3 rounds with each weapon type at the Shooting Range. The Shooting Range can be visited inside any AmmuNation.
Score at least a Bronze in all 12 lessons at Flight School. Flight School unlocks while preparing for The Merryweather Heist.
Go parachuting. The parachute is found at the tram station at the Summit of Mount Chiliad.
Participate in golf, darts, and tennis at least once, and enter 3 triathlon races.
Complete all 6 Off-Road Races. Off-Road races unlock after completing Crystal Maze with Trevor.
Complete all of Tonya's towing missions with Franklin.
Complete all of Beverly's paparazzo missions with Franklin.
Complete all of Hao's Shift Work mission with Franklin.
Complete all of Barry's missions with Franklin.
Complete all of Fanatic's missions with Franklin.
Complete all 4 of Dom's extreme missions.
Collect and return all 50 Space Ship parts to Omega.
Collecting all 50 Letter Scraps and complete the Dreyfuss' confrontation.
Complete 14 Random Events. When the radar flashes white and blue dot appears, go to the location for a random event.
Complete all 25 Under the Bridges
Complete all 8 Knife Flights.
Complete all 25 Stunt Jumps.
Purchase 5 money-generating properties. More will be available for purchase as the game progresses.
Purchase a vehicle on the web.
Visit the cinema.
Walk and play with Chop.
Hire a prostitute.
Make a booty call to a stripper.
Rob a shop.
Complete 4 friend activities: go to a bar, visit a strip club, watch a movie, and play dart with at least two of the game's protagonists.