It completely depends on what goals you're going for. If you want to complete the main quest line or the Fighters' Guild you should go with something more on the lines of heavy armor,blade/blunt,and block,with your race being Orc/Redguard,birthsign being "The Warrior",and class being on the lines of barbarian or knight.(My custom class that won me the game is called militia,race is redguard,major skills are armorer,blade,block,blunt,H2H,heavy armor,and acrobatics) If you want to become Arch-Mage(which is also helpful for main questling,I.E. "Staff of Worms",conjuration magic) you should have a Breton with "The Mage" birthsign and specialize in all magic types and alchemy(or a weapon such as blade). But be prepared for the many powerful enemies up ahead. If you want the Thieves' Guild or the Dark Brotherhood you should have an Argonian,Khajiit or Bosmer(Wood Elf),have one of the three birthsigns,which are mainly "The Steed","The Shadow",and"The Theif",specializing in sneak,security,blade/blunt,light armor,athletics,acrobatics,and mercantile/speechcraft/marksmen.