well you can finish the main quest ,DLC quests and many side quest ..but
the other quests wont end the game auto re-span new quests (same old ,small and not important quests )..like getting a quest from a random warrior or adventure on any random road in skyrim.
and random courier missions from a friend.
there are over 100 shouts even in the venila version so...those letter quest will be coming till they all are found.
and we have the continuous events like collecting ingredients and gems for the college ...and we always have the jarls mission to kill some giant ,bandits and dragon ect..
and not to forget the the DARK BROTHERHOOD forever which will never end.and vex and Devlin's JOBS
so the bottom line is no the game is designed to give the player something to do . only way to end the game is by quiting it
but if you want new quests , you could get DLC's like dwangaurd,heart-fire,dragon born...
if you don't want to spend any cash i highly recommend you to visit SKYRIMNEXUS ..you can download all new ,better mods for free.some are better than the DLC 's like FALSKAR